Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C. (2018). IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 20(8):942-953.

González C, Cornejo VH, Couve A. (2018). Golgi bypass for local delivery of axonal proteins, fact or fiction? Curr Opin Cell Biol. 6;53:9-14.


Salech, F., Varela-Nallar L., Arredondo, S., Bustamante, D.B., Andaur, G.A., Cisneros, R., Ponce, D., Inestrosa, N.C., Valdés, J.L., Behrens, M.I., Couve, A. (2017). Klotho regulates neuronal progenitor proliferation in the adult hippocampus. J Gerontol A Biol Sci Med Sci. 2017 Dec 30. doi: 10.1093/gerona/glx248.

Luarte, A., Cornejo, V.H., Bertin1, F., Gallardo, J. and Couve, A. (2017). The axonal endoplasmic reticulum: one organelle – many functions indevelopment, maintenance and plasticity. Developmental Neurobiology. 78(3):181-208.


Mardones, M.D., Andaur, G.A., Varas-Godoy, M., Henríquez, J.F., Salech, F., Behrens, M.I., Couve, A., Inestrosa, N.C., Varela-Nallar, L. (2016). Frizzled-1 receptor regulates adult hippocampal neurogenesis. Mol Brain. 9(1):29.

González, C., Cánovas, J., Fresno, J., Couve, E., Court, F.A., Couve A. (2016). Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve. Proc Natl Acad Sci U S A. 113(7):1823-8.


Loyola, P., Martínez, G., Muñoz, Velásquez, J. D., Maldonado, P., Couve, A. (2015). Combining Eye Tracking and Pupillary Dilation Analysis to Identify Website Key Objects. Neurocomputing.168: 179-189.

Quassollo, G., Wojnacki, J., Salas, D.A., Gastaldi, L., Marzolo, M.P., Conde, C., Bisbal, M., Couve, A., Cáceres, A. (2015). A RhoA signaling pathway regulates Golgi outpost formation. Curr Biol. 25(8):971-82.


Couve, A., and Hetz, C. (2014). RESETing ER proteostasis: selective stress pathway hidden in the secretory route. EMBO J. 33(21):2444-6.

Valenzuela, J.I., Jaureguiberry-Bravo, M., Salas, D.A., Ramírez, O.A., Cornejo, V.H., Lu, H.E., Blanpied, T.A., Couve, A. Transport along the dendritic endoplasmic reticulum defines the trafficking modality for GABAB receptors. J Cell Sci. 2014 Jun 3. pii: jcs.151092. [Epub ahead of print]

Couve, A., Kittler, J.T. Preface. Trafficking of organelles and proteins in the nervous system. Semin Cell Dev Biol. 2014 Mar;27:1-2.

González, C., Couve, A. The axonal endoplasmic reticulum and protein trafficking: cellular bootlegging south of the soma. Semin Cell Dev Biol. 2014 Mar;27:23-31.


Lazo, O.M., Gonzalez, A., Ascaño, M., Kuruvilla, R., Couve, A., Bronfman, F.C. (2013). BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching. JNeurosci. 33(14):6112-6122.


Valdés, V., Valenzuela, J.I., Salas, D.A., Jaureguiberry-Bravo, M., Otero, C., Ramírez, O.A., Thiede, C., Schmidt, C.F., Couve, A (2012). Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. PLoS ONE. 7(8):e44168.

Vidal R.L., Fuentes P., Valenzuela J.I., Alvarado C, Ramírez O.A., Kukuljan M., Couve A. (2012). RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Mol Cell Neurosci. 51(1-2):1-11.


Valenzuela, J.I., Jaureguiberry-Bravo, M., Couve, A. (2011). Neuronal protein trafficking: emerging consequences of ER dynamics. Mol Cell Neurosci. Invited review. 48:269-77.

Ramírez, O.A., Härtel, S., Couve, A (2011). Location matters: the endoplasmic reticulum and protein trafficking in dendrites. Biol. Res. 44:17-23

Ramírez, O.A., Couve, A (2011). The endoplasmic reticulum and protein trafficking in dendrites and axons. Trends in Cell Biology,21(4):219-27.

Vidal, R., Caballero, B., Couve, A., Hetz, C. (2011). Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington’s Disease. Curr Mol Med. 11(1):1-12.


Ramírez, O., Rojas, R., Couve, A. Härtel, S. (2010). Confined Displacement Algorithm (CDA) Determines True and Random Colocalization in Fluorescence Microscopy. J. Microsc. 239(3):173-83.

Terunuma, M., Vargas, K.J., Wilkins, M.E., Ramírez, O.A., Jaureguiberry-Bravo, M., Pangalos, M.N., Smart, T.G., Moss, S.J., Couve, A. (2010). Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc. Natl. Acad. Sci. 107(31):13918-23.

Cuitiño, L., Godoy, J.A., Bonansco, C., Couve, A., Fuenzalida, M., Inestrosa, N.C. (2010). Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons. J. Neurosci. 30(25):8411-20.


Tretter, V., Revilla-Sanchez, R., Houston, C., Terunuma, M., Havekes, R., Florian, C., Jurd, R., Vithlani, M., Michels, G., Couve, A., Sieghart, W., Brandon, N., Abel, T., Smart, T.G., Moss, S.J. (2009). Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc. Natl. Acad. Sci. 106(47):20039-44

Vidal, R.L., Valenzuela, J.I., Lujan, R., Couve, A. (2009). Cellular and subcellular localization of Marlin-1 in the brain. BMC Neuroscience 10:37.

Ramírez, O.A., Vidal, R.L., Tello, J.A., Vargas, K., Kindler, S., Härtel, S., Couve, A. (2009). Dendritic assembly of GABAB receptor subunits in hippocampal neurons. J. Biol. Chem. 284(19):13077-85.


Vargas, K., Terunuma, M., Tello, J.A., Pangalos, M.N., Moss, S.J., Couve, A. (2008). The availability of surface GABAB receptors is independent of GABA but controlled by glutamate in central neurons. J. Biol. Chem. 283(36):24641-8.

Vidal, R.L., Ramírez, A., Castro, M., Concha, I.I., Couve, A. (2008). Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors. J. Cell. Biochem. 103(3):886-95.


Vidal, R.L., Ramirez, O.A., Sandoval, L., Koenig-Robert, R., Hartel, S., Couve, A. (2007). Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport. Mol. Cell. Neurosci. 35(3):501-12.

Kuramoto, N., Wilkins, M., Fairfax, B., Revilla-Sanchez, R., Tamaki, K., Couve, A., Calver, A., Horvath, Z., Freeman, K., Carling, D., Huang, L., Cooper, E., Gonzalez, C., Smart, T., Pangalos, M.N., Moss, S.J. (2007). Phosphorylation and functional modulation of GABAB receptors via a direct interaction with the metabolic sensor AMP-dependent protein kinase. Neuron. 53(2):233-47.

The GABA Receptors, 3rd edition. Chapter: “Phosphorylation, desensitization and associated proteins: some anomalies in the function of the GABAB heterodimer”. Andrés Couve, Stephen J. Moss and Menelas Pangalos. Sam Enna and Hanns Möhler Editors. Humana Press. Totowa, NJ, USA. 2007


Restituito, S., Couve, A., Bawagan, H., Jourdain, S., Pangalos, M.N., Calver, A.R., Freeman, K.B., Moss, S.J. (2005). Multiple motifs regulate the trafficking of GABAB receptors at distinct checkpoints within the secretory pathway. Mol. Cell. Neurosci. 28(4):747-56.


Thuault, S.J., Brown, J.T., Sheardown, S.A., Jourdain, S., Fairfax, B., Spencer, J.P., Restituito, S., Nation J.H.L., Topps, S., Medhurst, A.D., Randall, A.D., Couve, A., Moss, S.J., Collingridge, G.L., Pangalos, M.N., Davies, C.H., Calver, A.R. (2004). The GABAB2 subunit is critical for the trafficking and function of native GABAB receptors. Biochem. Pharmacol. 68(8):1655-66.

Couve, A., Restituito, S., Brandon, J.M., Charles, K.J., Bawagan, H., Freeman, K.B., Pangalos, M.N., Calver, A.R., Moss, S.J. (2004). Marlin-1 a novel RNA binding protein associates with GABAB receptors. J. Biol. Chem. 279(14):13934-13943.

Fairfax, B.P., Pitcher, J.A., Scott, M.G., Calver, A.R., Pangalos, M.N., Moss, S.J., Couve, A. (2004). Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J. Biol. Chem. 279(13):12565-12573

Couve, A., Calver, A.R., Fairfax, B., Moss, S.J. and Pangalos, M.N. (2004). Unravelling the unusual signalling properties of the GABAB receptor. Biochem. Pharmacol. 68(8): 1527-1536.


Couve, A., Thomas, P., Calver, A.R., Hirst, W.D., Pangalos, M.N., Walsh, F.S., Smart, T.G., Moss, S.J. (2002). Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nature Neurosci. 5 (5): 415-424.


Robbins, M.J., Calver, A.R., Filippov, A.K., Russell, R.B., Wood, M.D., Cosio, C., Rice, S.Q., Babbs, A.J., Hirst, W.D., Boyfield, I., Price, G.W., Couve, A., Brown, D.A., Moss, S.J., Pangalos, M.N. (2001). GABAB2 is essential for G protein coupling of the GABAB receptor heterodimer. J. Neurosci. 21 (20): 8043-8052.


Couve, A., Kittler, J.T., Uren, J.M., Calver, A.R., Pangalos, M.N., Walsh, F.S., Moss, S.J. (2000). Association of GABAB receptors and members of the 14-3-3 family of signaling proteins. Mol. Cell. Neurosci. 17 (2): 317-328.

Calver, A.R., Robbins, M.J., Cosio, C., Rice, S.Q., Babbs, A.J., Hirst, W.D., Boyfield, I., Russell, R.B., Price, G.W., Couve, A., Moss, S.J., Pangalos, M.N. (2000). The C-terminal domains of the GABAB receptor subunits mediate intracellular trafficking but are not required for receptor signalling. J. Neurosci. 21 (4): 1203-1210.

Calver, A.R., Medhurst, A.D., Robbins, M.J., Charles, K.J., Evans, M.L., Harrison, D.C., Stammers, M., Hughes, S.A., Hervieu, G., Couve, A., Moss, S.J., Middlemiss, D.N., Pangalos, M.N. (2000) The expression of GABA(B1) and GABA(B2) receptor subunits in the CNS differs from that in peripheral tissues. Neuroscience. 100 (1): 155-170.

Filippov, A. K., Couve, A., Pangalos, M. N., Walsh, F.S., Brown, D.A., Moss, S.J. (2000). Heteromeric assembly of GABABR1 and GABABR2 receptor subunits inhibits Ca2+ current in sympathetic neurons. J. Neurosci. 20 (8): 2867-2874 (Filippov, A. K. and Couve, A. contributed equally to this work).

Couve, A., Moss, S.J and Pangalos, M.N. (2000). GABAB receptors: a new paradigm in G protein signalling. Mol. Cell. Neurosci. 16: 296-312.


Kim, J., Couve, A., Hirsch J. P. (1999). Receptor inhibition of pheromone signaling is mediated by the Ste4p Gb subunit. Mol. Cell. Biol. 19 (1): 441-449.

Brandon, N.J., Bedford, F.K., Connolly, C.N., Couve, A., Kittler, J.T., Hanley, J.G., Jovanovic, J.N., Uren, J., Taylor, P., Thomas, P., Smart, T.G., Moss, S.J. (1999). Synaptic targeting and regulation of GABA(A) receptors. Biochem. Soc. Trans. Aug; 27 (4): 527-530.


Couve, A., Filippov, A. K., Connolly, C. N., Bettler, B., Brown, D. A., Moss, S. J. (1998). Intracellular retention of recombinant GABAB receptors. J. Biol. Chem. 273 (41): 26361-26367.


Couve, A. and Hirsch, J. P. (1996). Loss of sustained Fus3p kinase activity and the G1 arrest response in cells expressing an inappropriate pheromone receptor. Mol. Cell. Biol. 16: 4478-4485.


Couve, A., Protopopov, V. and Gerst, J. E. (1995). Yeast synaptobrevin homologs are modified posttranslationally by the addition of palmitate. Proc. Natl. Acad. Sci. USA, 92: 5987-5991.


Couve, A. and Gerst, J. E. (1994). Yeast Snc proteins complex with Sec9. J. Biol. Chem. 269: 23391-23394.


Couve, A. O., Konig, C., and Santos, M. J. (1992). Induction of peroxisomal enzymes and a 64 kDa peptide in cultured mouse macrophages treated with clofibrate. Exp. Cell Res. 202: 541-544.