Publications

2016

Mardones, M.D., Andaur, G.A., Varas-Godoy, M., Henríquez, J.F., Salech, F., Behrens, M.I., Couve, A., Inestrosa, N.C., Varela-Nallar, L. (2016). Frizzled-1 receptor regulates adult hippocampal neurogenesis. Mol Brain. 9(1):29.

González, C., Cánovas, J., Fresno, J., Couve, E., Court, F.A., Couve A. (2016). Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve. Proc Natl Acad Sci U S A. 113(7):1823-8.

2015

Loyola, P., Martínez, G., Muñoz, Velásquez, J. D., Maldonado, P., Couve, A. (2015). Combining Eye Tracking and Pupillary Dilation Analysis to Identify Website Key Objects. Neurocomputing.168: 179-189.

Quassollo, G., Wojnacki, J., Salas, D.A., Gastaldi, L., Marzolo, M.P., Conde, C., Bisbal, M., Couve, A., Cáceres, A. (2015). A RhoA signaling pathway regulates Golgi outpost formation. Curr Biol. 25(8):971-82.

2014

Couve, A., and Hetz, C. (2014). RESETing ER proteostasis: selective stress pathway hidden in the secretory route. EMBO J. 33(21):2444-6.

Valenzuela, J.I., Jaureguiberry-Bravo, M., Salas, D.A., Ramírez, O.A., Cornejo, V.H., Lu, H.E., Blanpied, T.A., Couve, A. Transport along the dendritic endoplasmic reticulum defines the trafficking modality for GABAB receptors. J Cell Sci. 2014 Jun 3. pii: jcs.151092. [Epub ahead of print]

Couve, A., Kittler, J.T. Preface. Trafficking of organelles and proteins in the nervous system. Semin Cell Dev Biol. 2014 Mar;27:1-2.

González, C., Couve, A. The axonal endoplasmic reticulum and protein trafficking: cellular bootlegging south of the soma. Semin Cell Dev Biol. 2014 Mar;27:23-31.

2013

Lazo, O.M., Gonzalez, A., Ascaño, M., Kuruvilla, R., Couve, A., Bronfman, F.C. (2013). BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching. JNeurosci. 33(14):6112-6122.

2012

Valdés, V., Valenzuela, J.I., Salas, D.A., Jaureguiberry-Bravo, M., Otero, C., Ramírez, O.A., Thiede, C., Schmidt, C.F., Couve, A (2012). Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. PLoS ONE. 7(8):e44168.

Vidal R.L., Fuentes P., Valenzuela J.I., Alvarado C, Ramírez O.A., Kukuljan M., Couve A. (2012). RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Mol Cell Neurosci. 51(1-2):1-11.

2011

Valenzuela, J.I., Jaureguiberry-Bravo, M., Couve, A. (2011). Neuronal protein trafficking: emerging consequences of ER dynamics. Mol Cell Neurosci. Invited review. 48:269-77.

Ramírez, O.A., Härtel, S., Couve, A (2011). Location matters: the endoplasmic reticulum and protein trafficking in dendrites. Biol. Res. 44:17-23

Ramírez, O.A., Couve, A (2011). The endoplasmic reticulum and protein trafficking in dendrites and axons. Trends in Cell Biology,21(4):219-27.

Vidal, R., Caballero, B., Couve, A., Hetz, C. (2011). Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington’s Disease. Curr Mol Med. 11(1):1-12.

2010

Ramírez, O., Rojas, R., Couve, A. Härtel, S. (2010). Confined Displacement Algorithm (CDA) Determines True and Random Colocalization in Fluorescence Microscopy. J. Microsc. 239(3):173-83.

Terunuma, M., Vargas, K.J., Wilkins, M.E., Ramírez, O.A., Jaureguiberry-Bravo, M., Pangalos, M.N., Smart, T.G., Moss, S.J., Couve, A. (2010). Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc. Natl. Acad. Sci. 107(31):13918-23.

Cuitiño, L., Godoy, J.A., Bonansco, C., Couve, A., Fuenzalida, M., Inestrosa, N.C. (2010). Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons. J. Neurosci. 30(25):8411-20.

2009

Tretter, V., Revilla-Sanchez, R., Houston, C., Terunuma, M., Havekes, R., Florian, C., Jurd, R., Vithlani, M., Michels, G., Couve, A., Sieghart, W., Brandon, N., Abel, T., Smart, T.G., Moss, S.J. (2009). Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc. Natl. Acad. Sci. 106(47):20039-44

Vidal, R.L., Valenzuela, J.I., Lujan, R., Couve, A. (2009). Cellular and subcellular localization of Marlin-1 in the brain. BMC Neuroscience 10:37.

Ramírez, O.A., Vidal, R.L., Tello, J.A., Vargas, K., Kindler, S., Härtel, S., Couve, A. (2009). Dendritic assembly of GABAB receptor subunits in hippocampal neurons. J. Biol. Chem. 284(19):13077-85.

2008

Vargas, K., Terunuma, M., Tello, J.A., Pangalos, M.N., Moss, S.J., Couve, A. (2008). The availability of surface GABAB receptors is independent of GABA but controlled by glutamate in central neurons. J. Biol. Chem. 283(36):24641-8.

Vidal, R.L., Ramírez, A., Castro, M., Concha, I.I., Couve, A. (2008). Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors. J. Cell. Biochem. 103(3):886-95.

2007

Vidal, R.L., Ramirez, O.A., Sandoval, L., Koenig-Robert, R., Hartel, S., Couve, A. (2007). Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport. Mol. Cell. Neurosci. 35(3):501-12.

Kuramoto, N., Wilkins, M., Fairfax, B., Revilla-Sanchez, R., Tamaki, K., Couve, A., Calver, A., Horvath, Z., Freeman, K., Carling, D., Huang, L., Cooper, E., Gonzalez, C., Smart, T., Pangalos, M.N., Moss, S.J. (2007). Phosphorylation and functional modulation of GABAB receptors via a direct interaction with the metabolic sensor AMP-dependent protein kinase. Neuron. 53(2):233-47.

The GABA Receptors, 3rd edition. Chapter: “Phosphorylation, desensitization and associated proteins: some anomalies in the function of the GABAB heterodimer”. Andrés Couve, Stephen J. Moss and Menelas Pangalos. Sam Enna and Hanns Möhler Editors. Humana Press. Totowa, NJ, USA. 2007

2005

Restituito, S., Couve, A., Bawagan, H., Jourdain, S., Pangalos, M.N., Calver, A.R., Freeman, K.B., Moss, S.J. (2005). Multiple motifs regulate the trafficking of GABAB receptors at distinct checkpoints within the secretory pathway. Mol. Cell. Neurosci. 28(4):747-56.

2004

Thuault, S.J., Brown, J.T., Sheardown, S.A., Jourdain, S., Fairfax, B., Spencer, J.P., Restituito, S., Nation J.H.L., Topps, S., Medhurst, A.D., Randall, A.D., Couve, A., Moss, S.J., Collingridge, G.L., Pangalos, M.N., Davies, C.H., Calver, A.R. (2004). The GABAB2 subunit is critical for the trafficking and function of native GABAB receptors. Biochem. Pharmacol. 68(8):1655-66.

Couve, A., Restituito, S., Brandon, J.M., Charles, K.J., Bawagan, H., Freeman, K.B., Pangalos, M.N., Calver, A.R., Moss, S.J. (2004). Marlin-1 a novel RNA binding protein associates with GABAB receptors. J. Biol. Chem. 279(14):13934-13943.

Fairfax, B.P., Pitcher, J.A., Scott, M.G., Calver, A.R., Pangalos, M.N., Moss, S.J., Couve, A. (2004). Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J. Biol. Chem. 279(13):12565-12573

Couve, A., Calver, A.R., Fairfax, B., Moss, S.J. and Pangalos, M.N. (2004). Unravelling the unusual signalling properties of the GABAB receptor. Biochem. Pharmacol. 68(8): 1527-1536.

2002

Couve, A., Thomas, P., Calver, A.R., Hirst, W.D., Pangalos, M.N., Walsh, F.S., Smart, T.G., Moss, S.J. (2002). Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nature Neurosci. 5 (5): 415-424.

2001

Robbins, M.J., Calver, A.R., Filippov, A.K., Russell, R.B., Wood, M.D., Cosio, C., Rice, S.Q., Babbs, A.J., Hirst, W.D., Boyfield, I., Price, G.W., Couve, A., Brown, D.A., Moss, S.J., Pangalos, M.N. (2001). GABAB2 is essential for G protein coupling of the GABAB receptor heterodimer. J. Neurosci. 21 (20): 8043-8052.

2000

Couve, A., Kittler, J.T., Uren, J.M., Calver, A.R., Pangalos, M.N., Walsh, F.S., Moss, S.J. (2000). Association of GABAB receptors and members of the 14-3-3 family of signaling proteins. Mol. Cell. Neurosci. 17 (2): 317-328.

Calver, A.R., Robbins, M.J., Cosio, C., Rice, S.Q., Babbs, A.J., Hirst, W.D., Boyfield, I., Russell, R.B., Price, G.W., Couve, A., Moss, S.J., Pangalos, M.N. (2000). The C-terminal domains of the GABAB receptor subunits mediate intracellular trafficking but are not required for receptor signalling. J. Neurosci. 21 (4): 1203-1210.

Calver, A.R., Medhurst, A.D., Robbins, M.J., Charles, K.J., Evans, M.L., Harrison, D.C., Stammers, M., Hughes, S.A., Hervieu, G., Couve, A., Moss, S.J., Middlemiss, D.N., Pangalos, M.N. (2000) The expression of GABA(B1) and GABA(B2) receptor subunits in the CNS differs from that in peripheral tissues. Neuroscience. 100 (1): 155-170.

Filippov, A. K., Couve, A., Pangalos, M. N., Walsh, F.S., Brown, D.A., Moss, S.J. (2000). Heteromeric assembly of GABABR1 and GABABR2 receptor subunits inhibits Ca2+ current in sympathetic neurons. J. Neurosci. 20 (8): 2867-2874 (Filippov, A. K. and Couve, A. contributed equally to this work).

Couve, A., Moss, S.J and Pangalos, M.N. (2000). GABAB receptors: a new paradigm in G protein signalling. Mol. Cell. Neurosci. 16: 296-312.

1999

Kim, J., Couve, A., Hirsch J. P. (1999). Receptor inhibition of pheromone signaling is mediated by the Ste4p Gb subunit. Mol. Cell. Biol. 19 (1): 441-449.

Brandon, N.J., Bedford, F.K., Connolly, C.N., Couve, A., Kittler, J.T., Hanley, J.G., Jovanovic, J.N., Uren, J., Taylor, P., Thomas, P., Smart, T.G., Moss, S.J. (1999). Synaptic targeting and regulation of GABA(A) receptors. Biochem. Soc. Trans. Aug; 27 (4): 527-530.

1998

Couve, A., Filippov, A. K., Connolly, C. N., Bettler, B., Brown, D. A., Moss, S. J. (1998). Intracellular retention of recombinant GABAB receptors. J. Biol. Chem. 273 (41): 26361-26367.

1996

Couve, A. and Hirsch, J. P. (1996). Loss of sustained Fus3p kinase activity and the G1 arrest response in cells expressing an inappropriate pheromone receptor. Mol. Cell. Biol. 16: 4478-4485.

1995

Couve, A., Protopopov, V. and Gerst, J. E. (1995). Yeast synaptobrevin homologs are modified posttranslationally by the addition of palmitate. Proc. Natl. Acad. Sci. USA, 92: 5987-5991.

1994

Couve, A. and Gerst, J. E. (1994). Yeast Snc proteins complex with Sec9. J. Biol. Chem. 269: 23391-23394.

1992

Couve, A. O., Konig, C., and Santos, M. J. (1992). Induction of peroxisomal enzymes and a 64 kDa peptide in cultured mouse macrophages treated with clofibrate. Exp. Cell Res. 202: 541-544.