Welcome to the Couve lab. Our laboratory is broadly interested in understanding how features of the neuronal protein trafficking machinery have emerged from conserved principles and mechanisms of simpler cellular systems to accommodate the neuron’s specialized morphological demands.
We combine conventional molecular biology, cell biology and biochemistry with state-of-the-art fluorescent microscopy to tackle scientific projects focused on the role of the local ER in the transport and trafficking of neuronal proteins such as GABAB receptors and ion channels, in dendrites and axons. Other projects explore the role of ER dynamics on protein transport and how the ER structure influences Ca2+ signaling in neurons. Additionally we study the role of Marlin-1 in neuronal migration and the relationship between aging and neurogenesis.
The laboratory is located in Santiago at the Faculty of Medicine, University of Chile. The Faculty of Medicine is a rich scientific environment with a long-standing tradition in biomedical research and home to a number of graduate programs, including two of the most prestigious in the country: the Ph.D. Program in Biomedical Sciences and the Medical Specialist + Ph.D. Program in Medical Sciences.